Understanding the Correlation of Cotinine on Early Vascular Function Decline via Monocyte Chemotactic Protein-1 Activation in Smokers
DOI:
https://doi.org/10.62438/tunismed.v103i11.5886Keywords:
Cardiovascular risk, MCP-1, nitric oxide, cotinine, smokersAbstract
Introduction:Oxidative stress describes an imbalance of pro-oxidant and antioxidant levels in cells. This study aimed to investigate the significant correlation of Cotinine on Monocyte Chemotactic Protein-1 (MCP-1) and Nitric Oxide (NO) as an indicator of vascular function.
Methods:The research, designed as a comprehensive cross-sectional study, included a sample of non-smokers (n=100) and smokers (n=100). The study utilised Cotinine, MCP-1 Human MCP-1 ELISA kit, and Nitric Oxide Colorimetric Assay kit, with data analysis conducted using Wrap Partial Least Square.
Results: This study showed a significant effect between Cotinine with MCP-1 (p-value <0.001) and Cotinine with NO (p-value <0.029). The impact of MCP-1 on NO resulted in a p-value of <0.001. Indirectly, it can be known that the effect of Cotinine on NO through MCP-1 produces a p-value of <0.001.The study concluded a significant direct association between Cotinine and MCP-1, Cotinine and NO, and MCP-1 and NO. Meanwhile, the indirect relationship of Cotinine on NO through MCP-1 is paramount.
Conclusion:These findings underscore Cotinine's direct and indirect results on vascular function decline, contributing significantly to our understanding of vascular inflammation and providing a new perspective on the impact of smoking on cardiovascular health.
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