The yield of 24-hour ambulatory electrocardiography in the assessment of symptomatic school-age children

Authors

  • Khalil Ouaghlani Department of Pediatric Cardiology , La Rabta Hospital- Tunis- Tunisia
  • Meriem Drissa Department of Cardiology, Mongi Slim hospital, La Marsa- Tunis- Tunsia
  • Rihab Ben Othmen Department of Pediatric Cardiology. Hôpital la Rabta- Tunis- Tunisia
  • Hela Msaad Department of Pediatric Cardiology. Hôpital la Rabta- Tunis- Tunisia
  • Kaouther Hakim Department of Pediatric Cardiology. Hôpital la Rabta- Tunis- Tunisia
  • Fatma Ouarda Department of Pediatric Cardiology. Hôpital la Rabta- Tunis- Tunisia

Keywords:

children, arrhythmia , holter monitoring

Abstract

Introduction:

Light-headedness, syncope, dyspnea, chest pain, palpitation, loss of consciousness (LOC) or malaise are frequent reasons for consultation in school-age children (SAC). The yield of holter monitoring (HM) in the investigation of these symptoms in SAC is still controversial given the scarce studies.

Aim: 1/To determine the prevalence of baseline ECG abnormalities and those detected in HM in SAC and 2/ to assess the predictive factors of abnormal HM test. 

Methods: We conducted a retrospective descriptive study in which we included SAC (6 to 12 years old) presenting with syncope or light-headedness or palpitation, dyspnea, or chest pain, malaise or LOC and referred to our department for HM

Results: We included 366 children. Mean age was 9.7±1.88 years. The major symptoms experienced by the patients were: palpitation (50.7%), chest pain (16.9%), light-headedness (11.9%), syncope (6.9%), LOC (5.3%), ECG was abnormal in 8.7%. The two most common baseline ECG abnormalities were premature ventricular contractions (PVCs) (1.8%) and right bundle branch block (1.6%). HM was abnormal in 101 (26.6%) patients. The most common abnormalities in HM were vagal hypertonia in 61 patients (16.1%), PVCs in 29 patients (7.7%), Malignant abnormalities were encountered in 16 patients (13.9%). In the multivariate analysis: Age≥10 years, mean heart rate <94 beats per minute, syncope, LOC, malaise and PVCs on baseline ECG were identified as independent risk factors of abnormal holter.

Conclusion: HM has an important diagnostic value in symptomatic SAC. It allows the identification of benign as well as malignant arrhythmias.

Downloads

Download data is not yet available.

References

Harris JP. Cardiac arrhythmias. In: Thomas K, Henry M, Deborah E, dir. American academy of pediatrics textbook of pediatric care. United States: American Academy of Pediatrics; 2017. p. 141-81.

Friedman KG, Alexander ME. Chest pain and syncope in children: a practical approach to the diagnosis of cardiac disease. J Pediatr. 2013;163 (3):896-901.

Bisignani A, De Bonis S, Mancuso L, Ceravolo G, Bisignani G. Implantable loop recorder in clinical practice. J Arrhythm. 2018;35 (1):25-32.

Sarasin FP, Carballo D, Slama S, Louis Simonet M. Usefulness of 24-h Holter monitoring in patients with unexplained syncope and a high likelihood of arrhythmias. Int J Cardiol. 2005;101 (2):203-7.

Coupal KE, Heeney ND, Hockin BD, Ronsley R, Armstrong K, Sanatani S, et al. Pubertal hormonal changes and the autonomic nervous system: potential role in pediatric orthostatic intolerance. Front Neurosci. 2019;13:1197.

Kanjwal K, Calkins H. Syncope in children and adolescents. Cardiol Clin. 2015;33 (3):397-409.

Khairy P, Balaji S. Cardiac arrhythmias in congenital heart diseases. Indian Pacing Electrophysiol J. 2009;9 (6):299-317.

Hegazy RA, Lotfy WN. The value of holter monitoring in the assessment of pediatric patients. Indian Pacing Electrophysiol J. 2007;7 (4):204-14.

Mirabelli MC, Beavers SF, Chatterjee AB, Moorman JE. Age at asthma onset and subsequent asthma outcomes among adults with active asthma. Respir Med. 2013;107 (12):1829-36.

Ali S, Sobhy F, Abd El Aal M, Mahamoud S. Prospective study of holter monitoring in pediatric patients at sohag university hospital. World J Cardiovasc Dis. 2020;10 (7):460-72.

Aman R, Qureshi AU, Sadiq M. Yield of 48-hour holter monitoring in children with unexplained palpitations and significance of associated symptoms. J Pak Med Assoc. 2017;67 (7):975-9.

Ahn MS. Current concepts of premature ventricular contractions. J Lifestyle Med. 2013;3 (1):26–33.

Dorra Mbarek, Soufia Naccache, Meya Abdallah, Rami Tlili, Youssef Ben Ameur, Mohamed Rachid Boujnah. Extrasystole hisienne mimant un bloc auriculo-ventriculaire du 2ème degré. a propos d'une observation. Tunis Med. 2017;95 (2) : 145-148.

Dickinson DF. The normal ECG in childhood and adolescence. Heart. 2005;91 (12):1626-30.

Tadic M, Cuspidi C, Grassi G. Heart rate as a predictor of cardiovascular risk. Eur J Clin Invest. 2018;48 (3):e12892.

Wilders R. Sinus bradycardia in carriers of the SCN5A-1795insD mutation: unraveling the mechanism through computer simulations. Int J Mol Sci. 2018;19 (2):634.

Hegazy RA, Lofty WN, Ammar RI, Fattouh AM. Diagnostic dilemma of cardiac syncope in pediatric patients. Indian Pacing Electrophysiol J. 2008;8 (1):22-31.

Kilic A, Ozer S, Turanli G, Ayabakan C, Celiker A, Ozme S. Dysrhythmia as a cause of syncope in children without neurological or cardiac morphological abnormalities. Pediatr Int. 2002;44 (4):358-62.

Drago F, Santilli A, Turchetta A, Pompei E, Calzolari A. Diagnostic usefulness of holter monitoring in pediatric fainting and syncope. Minerva Pediatr. 1989;41 (5):235-9.

Wexler R, Pleister A, Raman S. Outpatient approach to palpitations. Am Fam Physician. 2011;84 (1):63-9. Kadish AH, Buxton AE, Kennedy HL, Knight BP, Mason JW, Schuger CD, et al. ACC/AHA clinical competence statement on electrocardiography and ambulatory electrocardiography: a report of the ACC/AHA/ACP-ASIM task force on clinical competence (ACC/AHA committee to develop a clinical competence statement on electrocardiography and ambulatory electrocardiography) endorsed by the international society for holter and noninvasive electrocardiology. Circulation. 2001;104 (25):3169-78.

Hoefman E, Bindels PE, Van Weert HM. Efficacy of diagnostic tools for detecting cardiac arrhythmias: systematic literature search. Neth Heart J. 2010;18 (11):543-51.

Knoebel SB, Crawford MH, Dunn MI, Fisch C, Forrester JS, Hutter AM, et al. Guidelines for ambulatory electrocardiography. A report of the American college of cardiology/American heart association task force on assessment of diagnostic and therapeutic cardiovascular procedures (subcommittee on ambulatory electrocardiography). Circulation. 1989;79 (1):206-15.

Additional Files

Published

2023-11-06

Issue

Section

Original articles

Categories