Polyphenols as Epigenetic Modulators of Health: A Holistic Approach to the Therapy and Prevention of Chronic Diseases
DOI:
https://doi.org/10.62438/tunismed.v103i10.5892Keywords:
Polyphenols, Epigenetics, Chronic Diseases, DNA Methylation, Epigenetic Modulators, Nutrigenomics, Antioxidants, Health, Therapeutic Strategies, PreventionAbstract
Background: The rising prevalence of chronic diseases, including cancer, metabolic disorders, neurodegenerative, and cardiovascular conditions, presents a growing challenge to modern medicine and public health.
Aim: This article investigates the potential of polyphenols as modulators of epigenetic mechanisms in the context of chronic disease.
Methods: A comprehensive review of scientific literature was conducted, with emphasis on key epigenetic processes such as DNA methylation, histone modifications, and microRNA regulation.
Results: Polyphenols like resveratrol, curcumin, quercetin, and catechins exert protective actions by modulating gene expression, counteracting harmful epigenetic changes, and supporting cellular health.
Conclusion: Advancing our understanding of how polyphenols influence epigenetic pathways may lead to innovative therapeutic strategies combining conventional and personalized approaches.
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