Diagnostic and therapeutic approach to endobronchial metastases from extra-thoracic neoplasms: A report of three cases and brief review of literature.

Authors

  • Soumaya Debiche Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, , Tunis, Tunisia
  • Houda Snene Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, , Tunis, Tunisia
  • Bochra Bouchabou Department of Gastroenterology,Mongi Slim La Marsa University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia
  • Monia Attia Department of Radiology,Mongi Slim La Marsa University Hospital,Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
  • Hana Blibech Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
  • Aïda Ayadi Department of Pathology Anatomy, Abderrahmen Mami University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Ariana, Tunisia
  • Rym Ennaifer Department of Gastroenterology,Mongi Slim La Marsa University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia
  • Leila Ben Farhat Department of Radiology,Mongi Slim La Marsa University Hospital,Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
  • Nadia Mehiri Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, , Tunis, Tunisia
  • Bechir Louzir Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia

DOI:

https://doi.org/10.62438/tunismed.v102i12.5202

Keywords:

Bronchoscopy, Case report, Colorectal cancer, Endobronchial, literature review, Metastasis, renal cancer

Abstract

 

Introduction: Endobronchial metastases (EBMs) are rare, with primary tumours predominantly of breast, renal, and colorectal origin. Bronchoscopy is the diagnostic gold standard, with histological confirmation through immunohistochemical study.

Cases: We presented three cases of EBMs, one secondary to colorectal cancer and two associated with renal tumours. EBM unveiled the extra-thoracic neoplasm in colorectal cancer and was incidentally discovered during renal cancer follow-up. Bronchoscopy revealed an obstructive endobronchial mass in two cases. Histological diagnosis was established via bronchial biopsies (collecting duct renal carcinoma), computed tomography-guided transparietal lung biopsy (clear cell renal carcinoma), and endobronchial mass resection through rigid bronchoscopy (colorectal adenocarcinoma).

Conclusion: In case of an endobronchial lesion, the diagnosis of EBM should be evoked especially when the medical history reports extra-thoracic neoplasms. This diagnostic hypothesis guides the histological diagnosis and leads to an appropriate treatment.

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Author Biographies

  • Bochra Bouchabou, Department of Gastroenterology,Mongi Slim La Marsa University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia

    Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Gastrologie, Tunis, Tunisie

  • Hana Blibech, Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia

     Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Pneumologie Allergologie, Tunis, Tunisie

  • Aïda Ayadi, Department of Pathology Anatomy, Abderrahmen Mami University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Ariana, Tunisia

    Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Abderrahmen Mami, Service d’anatomie pathologie, Ariana, Tunisie

  • Rym Ennaifer, Department of Gastroenterology,Mongi Slim La Marsa University Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia

    Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Gastrologie, Tunis, Tunisie

  • Leila Ben Farhat, Department of Radiology,Mongi Slim La Marsa University Hospital,Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia

    Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de radiologie, Tunis, Tunisie

  • Nadia Mehiri, Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, , Tunis, Tunisia

    Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Pneumologie Allergologie, Tunis, Tunisie

  • Bechir Louzir, Department of Pulmonology and Allergology, Mongi Slim University Hospital La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar,Tunis, Tunisia

    Université de Tunis El Manar, Faculté de Médecine de Tunis, CHU Mongi Slim La Marsa, Service de Pneumologie Allergologie, Tunis, Tunisie

References

Marchioni A, Lasagni A, Busca A, Cavazza A, Agostini L, Migaldi M, et al. Endobronchial metastasis: an epidemiologic and clinicopathologic study of 174 consecutive cases. Lung Cancer. 2014;84(3):222‑8.

Breta M, Arava S, Madan K, Singh A, Jain D, Guleria R. Endobronchial metastasis from extrathoracic malignancies: a clinicopathological study of 11 cases. Lung India. 2019;36(3):212.

Coriat R, Diaz O, De La Fouchardière C, Desseigne F, Négrier S. Endobronchial metastases from colorectal adenocarcinomas: clinical and endoscopic characteristics and patient prognosis. Oncology. 2007;73(5‑6):395‑400.

Kim AW, Liptay MJ, Saclarides TJ, Warren WH. Endobronchial colorectal metastasis versus primary lung cancer: a tale of two sleeve right upper lobectomies. Interact Cardiovasc Thorac Surg. 2009;9(2):379‑81.

Rosado Dawid NZ, Villegas Fernández FR, Rodríguez Cruz MDM, Ramos Meca A. Endobronchial metastases of colorectal cancer. Rev Esp Enferm Dig. 2016;108(4):232‑3.

Turner JF, Quan W, Zarogoulidis P, Browning RF. A case of pulmonary infiltrates in a patient with colon carcinoma. Case Rep Oncol. 2014;7(1):39‑42.

Kho SS, Yong MC, Chan SK, Tie ST, Voon PJ. Colon carcinoma with endobronchial metastasis masquerading as bronchial asthma causing ball valve effect. Med J Malaysia. 2018;73(6):403‑4.

Serbanescu GL, Anghel RM. Can endobronchial or endotracheal metastases appear from rectal adenocarcinoma? J Med Life. 2017;10(1):66‑9.

Charpidou A, Fotinou M, Alamara C, Kalkandi P, Tiniakou D, Alexopoulou K, et al. Report of two cases of endobronchial metastases secondary to colorectal cancer. In Vivo. 2007;21(1):133‑6.

Park CM, Goo JM, Choi HJ, Choi SH, Eo H, Im JG. Endobronchial metastasis from renal cell carcinoma: CT findings in four patients. Eur J Radiol. 2004;51(2):155‑9.

Poh M, Liam C, Pang Y, Chua K. Endobronchial metastasis from resected renal cell carcinoma causing total lung collapse. Respirol Case Rep. 2013;1(2):26‑7.

Kim MJ, Kim JI, Won KY, Lee HN. Solitary, Endobronchial metastasis from renal cell carcinoma 20 years after nephrectomy. J Korean Soc Radiol. 2021;82(4):994.

Zhang GL, Chen S, Li JD, Wang CG. Endobronchial metastasis of renal carcinoma: a case report and review of previous literature. Front Surg. 2021;8:658749.

Abdul Rahman SA, Abdul Rahman A, Rajab S, Mansour S, Mansour M, Salloum E, et al. Endobronchial metastasis secondary to occulting renal cell carcinoma: literature review and a rare case report. BMC Pulm Med. 2023;23(1):28.

Fournel C, Bertoletti L, Nguyen B, Vergnon JM. Endobronchial metastases from colorectal cancers: natural history and role of interventional bronchoscopy. Respiration. 2009;77(1):63‑9.

Lee SH, Jung JY, Kim DH, Lee SK, Kim SY, Kim EY, et al. Endobronchial metastases from extrathoracic malignancy. Yonsei Med J. 2013;54(2):403.

You JH, Jeong YB. Endobronchial metastasis of renal cancer presented as atelectasis. Case Rep Oncol. 2023;16(1):1048‑53.

Ikemura K, Lin DM, Martyn CP, Park JW, Seder CW, Gattuso P. Endobronchial metastasis from extrapulmonary neoplasms: analysis of clinicopathologic features and cytological evaluation by bronchial brushing. Lung. 2017;195(5):595‑9.

Tsuboi R, Oki M, Saka H, Kogure Y, Oka S, Nakahata M, et al. Rigid bronchoscopic intervention for endobronchial metastasis of renal cell carcinoma. Respir Investig. 2016;54(4):250‑4.

Doğan D, Turan D, Özgül MA, Çeti̇Nkaya E. The role of interventional pulmonology in endobronchial metastasis of renal cell carcinoma. Tuberk Toraks. 2019;67(3):211‑8.

Figure 2. (a) Protruding polypoid formation in the right upper lobar apical bronchus (black arrow) (endo-bronchial metastasis of renal cell carcinoma). (b) Axial slice in lung parenchyma

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Published

2024-12-01

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Vol. 102 No. 12 (2024): Tunis Med dec 2024

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Case report

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