Investigation de l’interet des cytokines inflammatoires et de Nouveaux biomarqueurs dans les cardiopathies ischemiques
DOI :
https://doi.org/10.62438/tunismed.v104i01.6454Mots-clés :
Biomarquers, Cytokines, Cardiopathie ischémique, angor stableRésumé
Introduction-Objectif : La cardiopathie ischémique est l'une des principales causes de mortalité et de morbidité dans le monde,résultantd'une reduction de l'apport sanguine au myocarde.Les biomarqueurs sont essentiels dans le diagnostic et la comprehension de la maladie.Cette étude explore l'utilité de nouveaux biomarqueurs (cytokines,PLA2 (phospholipaseA2),hs-CRP(protéineC-réactive hautement sensible),PCT(procalcitonine),H-FABP (protein de liaison aux acides gras de type cardiaque))pour diagnostiquer les cardiopathies ischémiques.
Méthodes :L'étude a été menée à l'hôpital cardiaque de Nasiriyah, en Irak, d'octobre2021 à octobre 2022. Elle a inclus 86 patients ayan tun angor stable,50 patients ayant un infarctus du myocarde (IDM)et des témoins sains.Les niveaux sériques des biomarqueurs et des cytokines Inflammatoires (TNF-α(facteur de nécrose tumorale alpha),IL-1β(interleukine-1bêta),IL-6
(interleukine-6),IL-9(interleukine-9))ont été measures par ELISA (essaiimmuno-enzymatique) et des immunoessais.
Résultats : Dans le groupe d’angor stable, l'étude a montré que le niveau de troponineI ne changeait pas de manière significative chez les patients. Cependant,par rapport aux témoins sains,les patients ont montré uneaugmentation significative des niveaux sériques de CK-MB(créatinekinase-
MB),demyoglobine,dehs-CRP,deH-FABP,deLp-PLA2(phospholipase A2 liée aux lipoprotéines) etdePCT.Des niveaux significativement élevés d’IL-6,IL-1β,IL-9etTNF-α
ont également été observes chez les patients par rapport aux témoins sains. Dans le groupe des patients ayant un-IDM,l'étude a révélé que le niveau de troponineI ne changeait pas de manière significative.Cependant,compares aux témoins,les patient sont montré une augmentation significative des niveaux demyoglobine,CK-MB,hs-CRP,Lp- PLA2,PCTetH-FABP.Des niveaux significativement élevés de sérumTNF-α,IL-9,IL-6 et IL-1β ont également été notés chez les patients par rapport aux témoins sains.
Conclusion : De nouveaux biomarqueurs telsqueH-FABP,PCT,Lp-PLA2 et les cytokines sont des outils ..( résumé tronqué à 250 mots).
Téléchargements
Références
RothGA,JohnsonC,AbajobirA,Abd-AllahF,AberaSF,AbyuG,etal.Global,Regional,
and National Burdenof Cardiovascular Diseases for 10 Causes,1990to2015.JAmColl Cardiol.2017 Jul 4;70(1):1–25.
ShibaHA,GalalSB,TagElDinKA,MohamedLA.A Case control study on ischemic heart disease and serum zinca tAl-Zahraa university hospital.JRecentAdvMed.2022Jul 26;3(2):108–18.
SeverinoP,D’AmatoA,PucciM,InfusinoF,AdamoF,BirtoloLI,etal.Ischemic Heart Disease Pathophysiology Paradigms Overview:From Plaque Activation to Microvascular Dysfunction. IntJ MolSci.2020Oct30;21(21):8118.
MozaffarianD,BenjaminEJ,GoAS,ArnettDK,BlahaMJ,CushmanM,etal.Heart
disease and stroke statistics--2015update:are por tfrom the American Heart Association. Circulation.2015Jan27;131(4):e29-322.
SavareseG,LundLH.Global PublicHealth Burden of Heart Failure. CardFail Rev.2017 Apr;3(1):7–11.
BulargaA,HungJ,DaghemM,StewartS,TaggartC,WereskiR,etal.Coronary Artery and Cardiac Disease in Patients With Type 2 Myocardial Infarction:A Prospective Cohort Study.Circulation.2022Apr19;145(16):1188–200.
SairamSG,SolaS,BarooahA,JavvajiSK,JaipuriaJ,VenkateshanV,etal.Theroleof Lp-PLA2 and biochemistry parameters as potential biomarkers of coronary artery disease in Asian South-Indians:a case-controlstudy. Cardiovasc DiagnTher.2017Dec;7(6):589–97.
PotterJM,HickmanPE,CullenL.Troponins in myocardial infarction and injury.Aust Prescr.2022Apr;45(2):53–7.
FakanyaWM,TothillIE. Detection of the inflammation biomarkerC-reactive proteinin serum samples:towards an optimal biosensor formula.Biosensors.2014Dec;4(4):340–57.
IbrahimMI,MohamedYM,TaherMA,AbdelrahmanMA.The Utility of Serum
Procalcitonin Levelas an Early Diagnostic Biomarker for COVID in Patients Presenting with ST-Elevation Myocardial Infarction Post Primary Percutaneous Coronary Intervention.EgyptJHosp Med.2023Jan 1;90(1):843–51.
Polonschii C,PotaraM,Iancu M,DavidS, BanciuRM, VasilescuA,etal. Progress in the Optical Sensing of Cardiac Biomarkers.Biosensors.2023 Jun 7;13(6):632.
YeXD, HeY, WangS,WongGT,Irwin MG,XiaZ.Heart-type fatty acid binding protein (H-FABP)as a biomarker for acute myocardial injury and long-termpost-ischemic prognosis.ActaPharmacol Sin.2018Jul;39(7):1155–63.
HayrapetyanH,TranT,Tellez-CorralesE,MadirajuC.Enzyme-Linked Immunosorbent Assay:Types and Applications.Methods MolBiolCliftonNJ. 2023;2612:1–17.
MahadevaraoPremnathS,ZubairM.Electrochemiluminescence Method.In:StatPearls
[Internet].TreasureIsland(FL):StatPearls Publishing; 2024[cited2024Nov22].Available from:http://www.ncbi.nlm.nih.gov/books/NBK594228/
WangC,LiuS,JuH.Electrochemiluminescencenanoemitters for immunoassay of protein biomarkers.BioelectrochemistryAmstNeth.2023Feb;149:108281.
KumariA,MishraP,ChaulyaSK,PrasadGM,NadeemM,KiskuV,etal.Estimation of
Soil Nutrients and Fertilizer Dosage UsingIon-Selective Electrodes for Efficient Soil
Management.CommunSoilSciPlantAnal. 2024;1–22.
McCarthyCP,McEvoyJW, JanuzziJL.Biomarkers instable coronary artery disease. Am HeartJ. 2018 Feb;196:82–96.
MajidiM,EslamiV,GhorbaniP,ForoughiM.Are women more susceptible to ischemic
heart disease compared to men?A literature over view.JGeriatrCardiolJGC.2021Apr 28;18(4):289–96.
DaněkJ,HnátekT,MalýM,TáborskýM,BěláčekJ,ŠkvarilJ,etal.Troponin levels in
patients with stable CAD. CorVasa.2017Jun 1;59(3):e229–34.
WJ,LA,KL,SjM,SE,CRR,etal.Necrotic cardiac myocytesskew macrophage polarization towards a classically activated phenotype.PloSOne[Internet].2023Mar30 [cited2024Nov22];18(3).Availablefrom:https://pubmed.ncbi.nlm.nih.gov/36996254/
MaayahM,Grubman S, AllenS,Ye Z,ParkDY, VemmouE,etal.Clinical Interpretation
of Serum Troponinin the Era of High-SensitivityT esting.Diagn BaselSwitz.2024Feb 26;14(5):503.
DuganiSB,AyalaMelendez AP,RekaR,HydoubYM,McCaffertySN,MuradMH,etal.
Risk factors associated with premature myocardial infarction:a systematic review protocol. BMJ Open.2019Feb11;9(2):e023647.
LiX,ZhangF,ZhouH,HuY,GuoD,FangX,etal.InterplayofTNF-α,solubleTNF
receptors andoxidative stress in coronary chronictotalocclusion of the oldest patients with coronaryheart disease.Cytokine. 2020 Jan;125:154836.
DaubertMA,JeremiasA.The utility of troponin measurement to detect myocardial
infarction:review of the current findings.VascHealthRiskManag.2010Sep7;6:691–9.
VikenesK,MelbergT,FarstadM,NordrehaugJE.ElevatedCK-MB values after routine
angioplasty predicts worselong-termprognosisinlow-riskpatients.ScandCardiovascJ SCJ.2010Apr;44(2):69–75.
WuP,Yu S,WangJ,ZouS, YaoDS,XiaochenY.Globalburden, trends,and inequalities
of ischemic heart disease among young adults from1990to2019:apopulation-basedstudy. FrontCardiovascMed.2023;10:1274663.
MotamedH,MohammadiM,TayebiZ,RafatiNavaeiA.The diagnostic utility of creatine
kinase-MBversustotalcreatinephosphokinaseratio in patients with non-ST elevation
myocardial infarction from unstable angina. SAGE Open Med. 2023;11:20503121221148609.
PopaDM,MacoveiL,MoscaluM,SascăuRA,StătescuC.ThePrognosticValueof
CreatineKinase-MB Dynamics after Primary Angioplasty in ST-Elevation Myocardial Infarctions.DiagnBasel Switz.2023Oct6;13(19):3143.
XuLQ,YangYM,TongH,XuCF.Early Diagnostic Performance of Heart-Type Fatty
Acid Binding Proteinin Suspected Acute Myocardial Infarction: Evidence From a Meta-
Analysis of Contemporary Studies. Heart LungCirc.2018 Apr;27(4):503–12.
AslSK,RahimzadeganM.There cent progress in the early diagnosis of acute myocardial
infarction based on myoglobin biomarker:Nano-aptasensorsapproaches.JPharm Biomed Anal.2022Mar20;211:114624.
LanzaGA,CareriG,CreaF.Mechanisms of coronary artery spasm.Circulation.2011Oct 18;124(16):1774–82.
WangQ,WangY,XuD.Research progress on Th 17 and Tregulatory cells and their cytokines in regulating atherosclerosis.Front Cardiovasc Med.2022;9:929078.
ŞahingözE,GöktaşA,MartlıHF,ErS,TezM,ŞahingözE,etal.Comparison of
pathologies in patients operated for transverse colon tumor with embryogenic and
anatomical insights.JComprSurg.2023 Nov30;1(4):66–70.
SmS,FA,RD,HD.Relationship between high-sensitivityC-reactive protein serum levels
and these verity of coronary artery stenosis in patients with coronary artery disease. ARYA
Atheroscler [Internet]. 2016 Sep [cited 2024 Nov 22];12(5). Available from: https://pubmed.ncbi.nlm.nih.gov/28458698/
AsakuraK,MinamiY,NagataT,KatamineM,KatsuraA,HashimotoT,etal.Impact of
theeicosapentaenoicacidtoarachidonicacidratioon plaque characteristics in statin-treated patients with coronary artery disease .JClinLipidol. 2023;17(1):189–96.
BestLG,ZhangY,LeeET,YehJL,CowanL,PalmieriV,etal.C-reactiveproteinasa
predictor of cardiovascular risk in a population with a high prevalence of diabetes: the StrongHeart Study. Circulation. 2005 Aug30;112(9):1289–95.
YousufO,MohantyBD,MartinSS,JoshiPH,BlahaMJ,NasirK,etal.High-sensitivity
C-reactive protein and cardiovascular disease: are solute belief or anelusive link?JAm Coll Cardiol. 2013Jul 30;62(5):397–408.
DevarajS,KumaresanPR,JialalI.EffectofC-reactive protein on chemokine expression
inhuman aorticendothelial cells. JMol CellCardiol. 2004 Mar;36(3):405–10.
LiuY,ZhangD,YinD.Pathophysiological Effects of Various Interleukinson Primary Cell
TypesinCommonHeart Disease. Int J MolSci.2023 Mar30;24(7):6497.
DingZ,WeiY,PengJ, WangS,ChenG,Sun J. The Potential Role of C-ReactiveProtein
in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging .Biomedicines. 2023 Oct 5;11(10):2711.
RezarR,JirakP,GschwandtnerM,DerlerR,FelderTK,HaslingerM,etal.Heart-Type
FattyAcid-BindingProtein(H-FABP)and itsRole as a Biomarker in Heart Failure:What
Do We Know So Far?J ClinMed. 2020 Jan 7;9(1):164.
XuC,ZhangT,ZhuB,CaoZ.Diagnostic role of postmortemCK-MBincardiac death:a
systematic review andmeta-analysis.ForensicSciMedPathol.2020Jun;16(2):287–94.
KabekkoduSP,MananjeSR,SayaRP.A Study on the Role of HeartType Fatty Acid
Binding Protein in theDiagnosis of Acute Myocardial Infarction.J ClinDiagn Res JCDR. 2016 Jan;10(1):OC07-10.
MatsumotoS,NakataniD, SakataY,SunaS,ShimizuM,UsamiM,etal.Elevated serum
heart-type fattyacid-binding proteinin the convalescent stage predicts long-term outcome
in patients surviving acute myocardial infarction.CircJOffJJpnCircSoc. 2013;77(4):1026–32.
LL,JT,YS,QX,BS,FX,etal.Lipoprotein-associated phospholipase A2predicts
cardiovascular death in patients on maintenance hemodialysis:a7-year prospectivecohort
study.LipidsHealthDis[Internet].2024Dec1[cited2024Nov22];23(1).Availablefrom:
https://pubmed.ncbi.nlm.nih.gov/38216940/
RacherlaS,AroraR.UtilityofLp-PLA2inlipid-loweringtherapy.AmJTher.2012 Mar;19(2):115–20.
DadaN,KimNW,WolfertRL.Lp-PLA2:an emerging biomarker of coronary heart
disease.Expert RevMol Diagn.2002 Jan;2(1):17–22.
AbbasiA,VahabiP,TabatabaeiSA,ShahrzadS,MostafaviA,NikdoustF.The Potential
Role of Serum Procalcitonin and Coronary Angiographic Findings in Patients With Acute
CoronarySyndromesEvaluatedbytheSYNTAXScore.IranHeartJ.2023Jul1;24(3):77–84.
SchuetzP,DanielsLB,KulkarniP,AnkerSD,MuellerB.Procalcitonin:A new biomarker fo rthe cardiologist.Int JCardiol.2016Nov 15;223:390–7.
ZakiHA,BenslimanS,BashirK,IftikharH,FayedMH,SalemW,etal.Accuracyof
procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department:
asystematicreviewandmeta-analysis.SystRev.2024Jan 22;13(1):37.
KellyD,KhanSQ,DhillonO,QuinnP,StruckJ,SquireIB,etal.Procalcitoninasa
prognostic marker in patients with acute myocardial infarction.BiomarkBiochemIndic
Expo Response Susceptibility Chem. 2010Jun;15(4):325–31.
HashemipourSV,PourhosseiniH,Hosseinsabet A. Correlation between the serum
procalciton in level and the extension and severity of coronary artery disease in patients with
non-ST-segment elevation myocardial infarction.Cardiovasc EndocrinolMetab.2019 Jun;8(2):62–6.
SultanRH,AbdallahM,AliTM,AhmedAE,AssalHH,ElesawyBH,etal.The
Associations between Cytokine Levels, Kidney and Heart Function Biomarkers, and
Expression Levels of Angiotensin-Converting Enzyme-2 and Neuropilin-1inCOVID-19 Patients.Vaccines.2022 Jun29;10(7):1045.
BouzidiN,GamraH.Relationship between serum interleukin-6 levels and severity of
coronary artery disease under going percutaneous coronary intervention.BMC Cardiovasc Disord.2023 Nov 28;23(1):586.
TøllefsenIM,SheteligC,SeljeflotI,EritslandJ,HoffmannP,AndersenGØ.High levels
ofinterleukin-6 are associated with final infarct size and adverse clinical events in patients with STEMI.Open Heart.2021Dec;8(2):e001869.
SuJH,LuoMY,LiangN,GongSX,ChenW,HuangWQ,etal.Interleukin-6:ANovel
Target for Cardio-Cerebrovascular Diseases. Front Pharmacol. 2021;12:745061.
Müller J,GorressenS,Grandoch M, Feldmann K,KretschmerI,Lehr S, etal.Interleukin-
-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction. BasicResCardiol. 2014;109(6):440.
Fernández-RuizI.Early inhibition ofIL-6 signalling after an acute MIimproves myocardial salvage.NatRevCardiol.2021Jul;18(7):460.
Białecka M,DziedziejkoV, SafranowK,KrzystolikA,MarcinowskaZ,ChlubekD, etal.
Could Tumor NecrosisFactor Serve asa Markerfor Cardiovascular Risk Factors and Left
Ventricular Hypertrophy in Patients with Early-Onset Coronary Artery Disease? Diagn BaselSwitz.2024Feb18;14(4):449.
FangC,ChenZ,ZhangJ,PanJ,JinX,YangM,etal.The Value of Serum YKL-40and
TNF-α in the Diagnosis of AcuteST-Segment Elevation Myocardial Infarction.Cardiol ResPract. 2022;2022:4905954.
HinkleyH,CountsDA,VonCanonE,Lacy M.TCellsinAtherosclerosis:KeyPlayersin
the Pathogenesis of VascularDisease.Cells. 2023Aug26;12(17):2152.
MahmoudAH,TahaNM,ZakharyM,TadrosMS.PTENgene&TNF-alphainacute
myocardial infarction.IntJ CardiolHeartVasc.2019Jun;23:100366.
PluijmertNJ,AtsmaDE,QuaxPHA.Post-ischemic Myocardial Inflammatory Response:
A Complex and Dynamic Process Susceptibleto Immunomodulatory Therapies.Front CardiovascMed. 2021;8:647785.
ToldoS,MauroAG,CutterZ,AbbateA.Inflammasome,pyroptosis,andcytokinesin
myocardialischemia-reperfusioninjury.AmJPhysiolHeartCircPhysiol.2018Dec 1;315(6):H1553–68.
MoriyaJ.Critical roles of inflammation in atherosclerosis.JCardiol.2019Jan;73(1):22–7.
RichterJ,BrouwerS,SchroderK,WalkerMJ.Inflamma some activationandIL-1β
signalling in group A Streptococcus disease.CellMicrobiol.2021Sep;23(9):e13373.
RidkerPM,MacFadyenJG,ThurenT,EverettBM,LibbyP,GlynnRJ,etal.Effectof
interleukin-1βinhibition with canakinumabon incident lung cancer in patients with
atherosclerosis: exploratory results from arandomised,double-blind,placebo-controlled
trial.Lancet LondEngl. 2017Oct21;390(10105):1833–42.
CappuzzelloC,DiVitoL, MelchionnaR,MelilloG,Silvestri L,CesareoE,etal.Increase
of plasma IL-9and decrease of plasmaIL-5,IL-7, andIFN-γ in patients with chronic heart failure.J TranslMed.2011 Mar21;9:28.
OrmstadH,AassHCD,Lund-SørensenN,AmthorKF,SandvikL.Serumlevelsof
cytokinesand C-reactive protein in acute ischemic stroke patients,and their relation ship to
stroke lateralization,type,and infarct volume.JNeurol.2011Apr;258(4):677–85.
Fichiers supplémentaires
Publiée
Licence
Merci de créditer les auteurs lors de toute citation : La Tunisie Médicale (2026)
Ce travail est disponible sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.
