Polymorphisme RS3744843 de la lipase endothéliale et profil lipidique chez les patients atteints de la maladie de Behçet
DOI :
https://doi.org/10.62438/tunismed.v104i03.6217Mots-clés :
Lipase endothéliale, polymorphisme, profil lipidique, inflammation, maladie de Behçet, vascularite multisystémiqueRésumé
Contexte : Le gène de lipase endothéliale (LIPG) est impliqué dans les modifications du profil lipidique, en particulier le métabolisme du HDL-C et
dans l’inflammation. Plusieurs polymorphismes à nucléotide unique (SNP) identifiés de LIPG étaient associés au métabolisme des lipoprotéines et
apolipoprotéines. L’implication du LIPG dans une inflammation chronique due à une vascularite multisystémique n’a pas été élucidée.
Objectif : Évaluer l’association entre le polymorphisme EL2037T/C(rs3744843) et les altérations des profils lipidiques et des biomarqueurs de dysfonction endothéliale (CRP à haute sensibilité à la protéine C réactive, homocystéine) chez les patients tunisiens atteints de la maladie de
Behçet (TB).
Méthodes : Une étude cas-témoins incluant des patients atteints de trouble bipolar avec des témoins a été réalisée. Le profil lipidique, la CRP et
l’homocystéine ont été évalués à tous les sujets. La méthode de polymorphisme de longueur des fragments de restriction par réaction en chaîne
par polymérase.
Résultats : Nous avons inclus 116 patients atteints de trouble bipolar et 102 contrôles sains dans cette étude. Les fréquences de TT. Les génotypes
TC et CC étaient respectivement : 90,52 %. 8,62 % et 0,86 % dans le groupe témoin contre 89,21 %. 10,78 % et 0 % dans le groupe BD. Nous n’avons
pas trouvé de différences significatives entre le groupe BD et le groupe témoin pour les distributions génotypique et allélique. Les niveaux de HDL-C
étaient significativement plus faibles chez les patients. Les porteurs témoins de l’allèle C ....( résumé tronqué à 250 mots)
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