Effet Synergique du Bruit et du Toluène sur les Altérations Hématologiques, le Stress Oxydatif Pulmonaire et l'Inflammation.
DOI :
https://doi.org/10.62438/tunismed.v103i10.5718Mots-clés :
Bruit, Toluène, Poumons, Coexposition , Stress oxydatif, Inflammation pulmonaireRésumé
Objectif : Etudier les effets synergiques de la co-exposition bruit-toluène sur, les paramètres hématologiques, le stress oxydatif et sur l'architecture pulmonaire chez le rat.
Méthode : 24 rats mâles Wistar ont été divisés en quatre groupes : témoin, exposition au bruit, exposition au toluène et co-exposition bruit-toluène.
Des analyses biologiques ont été réalisées pour déterminer les paramètres hématologiques et évaluer les marqueurs du stress oxydatif. Des coupes histopathologiques ont été observées pour évaluer les lésions tissulaires pulmonaires et le degré de réponse inflammatoire.
Résultats : La coexposition bruit-toluène a entraîné une augmentation significative de la peroxydation lipidique et une diminution de l'activité de la catalase et de la SOD.
L'analyse hématologique a révélé une diminution significative des globules rouges, accompagnée d'une augmentation dans le nombre de globules blancs et de plaquettes. L'examen histologique des tissus pulmonaires a révélé une inflammation avec des lésions des parois alvéolaires et une infiltration de cellules immunitaires péribronchiques dans le groupe co-exposé, ce qui était corrélé à une augmentation de la perméabilité vasculaire et à un œdème pulmonaire.
Conclusion : Les résultats suggèrent que l’exposition combinée au toluène et au bruit entraine un changement structural et fonctionnel au niveau des tissus pulmonaires et des modifications dans les paramètres hématologiques.
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