Effets de la spiruline enrichie en zinc comme adjuvant au traitement conventionnel des patients atteints de broncho-pneumopathie chronique obstructive : Protocole de recherche pour un essai clinique contrôlé randomisé Nord-Africain (SPIRICOPD)
DOI :
https://doi.org/10.62438/tunismed.v102i11.4947Mots-clés :
Broncho-pneumopathie chronique obstructive, spiruline, stress oxydatif, explorations fonctionnelles respiratoires, fonction endothélialeRésumé
Contexte : La broncho-pneumopathie chronique obstructive (BPCO) est une affection respiratoire fortement liée au stress oxydatif. Des études récentes ont exploré les avantages de la supplémentation nutritionnelle dans la prise en charge de plusieurs pathologies. Notre étude vise à examiner les effets d'une supplémentation en spiruline enrichie en zinc (SSZ) chez les patients atteints de BPCO.
Méthodes : Il s'agit d'un essai clinique contrôlé randomisé monocentrique incluant des hommes âgés de moins de 65 ans, suivis pour BPCO et bénéficiant d'un traitement médical conventionnel selon les recommandations GOLD2023. Quatre-vingt-dix sujets seront répartis au hasard entre le groupe expérimental (G1) et le groupe contrôle (G2) dans un ratio 1:1. Le G1 recevra la SSZ (1 g/jour) pendant 2 mois, tandis que le G2 poursuivra uniquement le traitement médical de base. L'étude évaluera la balance oxydant-antioxydant, la fonction pulmonaire, la capacité à l’exercice, le profil lipidique, la dyspnée et la qualité de vie. Tous les paramètres seront évalués au départ, immédiatement après la fin de la supplémentation, puis un mois plus tard. L'approbation éthique a été obtenue auprès du comité d'éthique de la faculté de médecine de Sousse.
Résultats attendus : On s'attend à ce que la SSZ puisse avoir un impact positif sur l'équilibre oxydant/antioxydant chez les patients atteints de BPCO. Les auteurs prévoient que la SSZ peut améliorer divers paramètres physiologiques, tels que la fonction pulmonaire, la capacité d'exercice, la fonction endothéliale et le profil métabolique, conduisant à une amélioration globale ...( résumé tronqué à 250 mots)
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