CARACTERISTIQUES CYTOLOGIQUES ET IMMUNOPHENOTYPIQUES DES LEUCEMIES A TRICHOLEUCOCYTES : A PROPOS DE 6 CAS
Mots-clés :
Leucémie à tricholeuchocytes, Cytomètrie de flux, Anticorps monoclonaux, Tricholeucocytes, CD103, CD11cRésumé
Pré-requis : La leucémie à tricholeucocytes est un syndrome lymphoprolifératif Brare.
Objectifs : Préciser les caractéristiques cytologiques et immunophénotypiques.
Méthodes : Nous rapportons une série de 6 cas de leucémies à tricholeucocytes diagnostiqués au Service d’Hématologie Biologique de l’Hôpital Aziza Othmana de Tunis.
Résultats : Le frottis sanguin objective la présence de tricholeucocytes dans 5 cas. L’immunophénotypage objective une population B monoclonale en fenêtrant sur l’expression du CD19 et le signal SSC. La positivité du CD103 est notée dans 5 cas et le signal CD11c est intense dans tous les cas.
Conclusion : L’immunophénotypage est d’un grand apport dans le diagnostic des leucémies à tricholeucocytes.
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