Immunogénétique du psoriasis : Actualités
Mots-clés :
Psoriasis, immunologie, génétiqueRésumé
Pré-requis : Le psoriasis est une dermatose érythémato-squameuse souvent bénigne, touchant 2 à 3% de l’ensemble de la population mondiale. Le psoriasis est une maladie multifactorielle.But : Présenter les dernières avancées concernant les mécanismes immunologiques et les gènes de prédisposition impliqués dans l’étiopathogénie du psoriasis.
Méthodes : Nous nous proposons de présenter une revue de la littérature récente des bases génétiques et immunologiques du psoriasis afin de mieux comprendre la physiopathologie du psoriasis et de discuter la contribution des travaux tunisiens dans ce domaine.
Résultats : Les travaux récents concernent essentiellement l’immunologie et la génétique. Les progrès actuels des techniques de biologie moléculaire ont permis de mieux caractériser les anomalies immunogénétiques au cours du psoriasis.
Conclusion : Le psoriasis est un modèle de maladie multifactorielle au cours de laquelle les facteurs environnementaux (psychiques, climatiques, traumatiques, infectieux, viraux) semblent être les agents révélateurs s’ils sont associés à un terrain immunogénétique particulier.
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Références
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