Impact des variantes de toll-like receptor 4 sur le risque et la survie au cours du carcinome de nasopharynx chez la population tunisienne
DOI :
https://doi.org/10.62438/tunismed.v102i2.4270Mots-clés :
carcinome du nasopharynx, TLR4, gène, polymorphisme, risqueRésumé
Introduction : Le Toll-like receptor 4 (TLR4), joue un rôle clé dans la réponse immune innée et la détection des microorganismes. La variation génétique du gène codant pour ce récepteur pourrait constituer un facteur prédisposant pour le carcinome du nasopharynx (CNP).
Objectif : L’objectif de cette étude était de déterminer l’association entre les variations du gène de ce récepteur et la susceptibilité au CNP dans une cohorte de patients tunisiens.
Méthodes : L’ADN génomique de 245 patients non apparentés atteints d'un carcinome de type indifférencié (UCNT) et de 264 témoins sains ont été génotypés pour les cinq polymorphismes nucléotidiques simples (SNP) du locus TLR4 (4434 A>G (rs1927914),7263 G>C (rs10759932), 6134 A>G(rs4986790), 8851C>T ( rs 4986791), 5272 T>C(rs11536889), +8469 T>C (rs11536891)) par la technique Taqman® 5’-nuclease. Parmi toutes les variations étudiées, seuls les allèles rs4986790G et 4986791 T étaient significativement plus fréquent chez les patients que chez les témoins (45% vs 38% ; p=0,03) et augmenterait le risque de NPC (OR=1,3, IC à 95%=1,01-1,69).
Résultats : En revanche, la fréquence des génotypes rs4986790 AA et rs4986791 TT était significativement plus élevée chez les témoins que chez les patients (25,7% vs 37% ; p=0,006) et conférerait un facteur protecteur contre le NPC (OR=0,59, IC à 95%=0,39-0,87). En outre, sur la base de la courbe de survie de Kaplan-Meier, l'effet positif du génotype AA rs1927914 a été observé sur le pronostic de NPC (p=0, 006).
Conclusion : Notre étude suggère que lers1927914 AA semble être un bon biomarqueur pour une meilleure survie chez un patient atteint de NPC.
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