Traitement médical de l’endométriose
Mots-clés :
Endométriose, traitement médical, pilules oestroprogestatives, progestatifs, anti-progestérones, danazol, agonistes de la GnRh, anti-inflammatoires non stéroidienRésumé
RESUME:Prérequis : La physiopathologie de l’endométriose, propriétés phamacodynamiques des pilules oestroprogestatives, des progestatifs, des anti-progestérones, du danazol, des agonistes de la GnRh et des anti-inflammatoires non stéroïdien
But du travail : Le but de ce travail est de rassembler les dernières données de la littérature et de faire une synthèse des dernières recommandations publiées sur le traitement médical de l’endométriose.
Méthodes: Revue de la littérature et des recommandations récentes concernant le traitement médical de l’endométriose à travers une recherche bibliographique sur les moteurs de recherche Pubmed/Medline, Google scholar et Cochrane database.
Résultats : L’endométriose est une pathologie oestrogénodépendante. Le but du traitement médical est d’induire un état d’hypo-oestrogénie. Les pilules oestroprogestatives diminuent significativement le taux de récidive post-opératoire des endométriomes et doivent être considéré dans la stratégie de prise en charge thérapeutique à long terme. Des nouvelles molécules paraissent prometteuses dans cette prise en charge.
Conclusions : L’efficacité du traitement médical dans la prise en charge des douleurs pelviennes et de l’infertilité dû à l’endométriose est établie. Ce traitement représente une alternative ou un complément à la prise en charge chirurgicale.
Téléchargements
Références
Spaczynski RZ, Duleba AJ. Diagnosis of endometriosis. Semin Reprod Med. 2003 ;21:193-208.
Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol. 2004 ;160:784-96.
Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012;98:511-9.
Medicine, Practice Committee of the American Society for Reproductive. Endometriosis and infertility: a committee opinion. Fertil Steril. 2012;98:591-8.
Medicine, Practice Committee of the American Society for Reproductive.. Treatment of pelvic pain associated with endometriosis: a committee opinion. Fertil Steril. 2014 ;101:927-35.
Thomin A, Daraï E, Chabbert-Buffet N. Traitements médicaux des tumeurs ovariennes présumées bénignes. J Gynecol Obstet Biol Reprod (Paris). 2013;42:774-85.
Bourdel N, Canis M. Stratégies thérapeutiques des tumeurs ovariennes présumées bénignes. J Gynecol Obstet Biol Reprod (Paris). 2013 ;42:802-15.
Dunselman GA, Vermeulen N, Becker C et al. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29:400- 12.
Johnson NP, Hummelshoj L. Consensus on current management of endometriosis. Hum Reprod. 2013;28:1552-68.
FM, Howard. Endometriosis and mechanisms of pelvic pain. J Minim Invasive Gynecol. 2009;16:540-50.
Marjoribanks J, Proctor M, Farquhar C, Derks RS. Nonsteroidal antiinflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev. 2010;(1):CD001751.
Vercellini P, Eskenazi B, Consonni D et al. Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis. Hum Reprod Update. 2011;17:159-70.
IM, Spitz. Clinical utility of progesterone receptor modulators and their effect on the endometrium. Curr Opin Obstet Gynecol. 2009;21:318-24.
Allen C, Hopewell S, Prentice A, Gregory D. Nonsteroidal antiinflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev. 2009;(2):CD004753.
Harada T, Momoeda M, Taketani Y, Hoshiai H, Terakawa N. Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial. Fertil Steril. 2008;90:1583-8.
Davis L, Kennedy SS, Moore J, Prentice A. Modern combined oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev. 2007;(3):CD001019.
Guzick DS, Huang LS, Broadman BA, Nealon M, Hornstein MD. Randomized trial of leuprolide versus continuous oral contraceptives in the treatment of endometriosis-associated pelvic pain. Fertil Steril. 2011;95:1568-73.
Crosignani PG, Luciano A, Ray A, Bergqvist A. Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain. Hum Reprod. 2006;21:248-56.
Strowitzki T, Faustmann T, Gerlinger C, Seitz C. Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol. 2010;151:193-8.
Cosson M, Querleu D, Donnez J. Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study. Fertil Steril. 2002;77:684-92.
Harada T, Momoeda M, Taketani Y et al. Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis--a randomized, double-blind, multicenter, controlled trial. Fertil Steril. 2009;91:675-81.
Strowitzki T, Marr J, Gerlinger C, Faustmann T, Seitz C. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial. Hum Reprod. 2010;25:633-41.
Strowitzki T1, Marr J, Gerlinger C, Faustmann T, Seitz C. Detailed analysis of a randomized, multicenter, comparative trial of dienogest versus leuprolide acetate in endometriosis. Int J Gynaecol Obstet. 2012;117:228-33.
Momoeda M, Harada T, Terakawa N. Long-term use of dienogest for the treatment of endometriosis. J Obstet Gynaecol Res. 2009;35:1069-76.
Petraglia F, Hornung D, Seitz C. Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment. Arch Gynecol Obstet. 2012;285:167-73.
Brown J, Kives S, Akhtar M. Progestagens and anti-progestagens for pain associated with endometriosis. Cochrane Database Syst Rev. 2012;(3):CD002122.
Brown J, Pan A, Hart RJ. Gonadotrophin-releasing hormone analogues for pain associated with endometriosis. Cochrane Database Syst Rev. 2010;(12):CD008475
Selak V, Farquhar C, Prentice A, Singla A. Danazol for pelvic pain associated with endometriosis. Cochrane Database Syst Rev. 2007;(4):CD000068.
Ferrero S, Gillott DJ, Venturini PL, Remorgida V. Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review. Reprod Biol Endocrinol. 2011;9:89.
Nawathe A, Patwardhan S, Yates D, Harrison GR, Khan KS. Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis. BJOG. 2008;115:818-22.
Pavone ME, Bulun SE. Aromatase inhibitors for the treatment of endometriosis. Fertil Steril. 2012;98:1370-9
Kettel LM, Murphy AA, Morales AJ, Ulmann A, Baulieu EE, Yen SS. Treatment of endometriosis with the antiprogesterone mifepristone (RU486). Fertil Steril. 1996;65:23-8.
Lv D, Song H, Shi G. Anti-TNF-alpha treatment for pelvic pain associated with endometriosis. Cochrane Database Syst Rev. 2010;(3):CD008088.
Lu D, Song H, Li Y, Clarke J, Shi G. Pentoxifylline for endometriosis. Cochrane Database Syst Rev. 2012;(1):CD007677.
Moravek MB, Ward EA, Lebovic DI. Thiazolidinediones as therapy for endometriosis: a case series. Gynecol Obstet Invest. 2009;68:167-70.
Stratton P, Sinaii N, Segars J. Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial. Obstet Gynecol. 2008;111:88-96.
Laschke MW, Menger MD. Anti-angiogenic treatment strategies for the therapy of endometriosis. Hum Reprod Update. 2012;18:682-702.
Zhu X, Hamilton KD, McNicol ED. Acupuncture for pain in endometriosis. Cochrane Database Syst Rev. 2011;(9):CD007864
Sesti F, Pietropolli A, Capozzolo T et al. Hormonal suppression treatment or dietary therapy versus placebo in the control of painful symptoms after conservative surgery for endometriosis stage III-IV. A randomized comparative trial. Fertil Steril. 2007;88:1541-7.
Koga K, Takemura Y, Osuga Y. Recurrence of ovarian endometrioma after laparoscopic excision. Hum Reprod. 2006;21:2171-4.
Liu X, Yuan L, Shen F, Zhu Z, Jiang H, Guo SW. Patterns of and risk factors for recurrence in women with ovarian endometriomas. Obstet Gynecol. 2007;109:1411-20.
Yap C, Furness S, Farquhar C. Pre and post operative medical therapy for endometriosis surgery. Cochrane Database Syst Rev. 2004;(3):CD003678.
Tsujioka H, Inoue Y, Emoto M. The efficacy of preoperative hormonal therapy before laparoscopic cystectomy of ovarian endometriomas. J Obstet Gynaecol Res. 2009;35:782-6.
Muzii L, Maneschi F, Marana R et al. Oral estroprogestins after laparoscopic surgery to excise endometriomas: continuous or cyclic administration? Results of a multicenter randomized study. J Minim Invasive Gynecol. 2011;18:173-8
Seracchioli R, Mabrouk M, Frascà C et al. Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial. Fertil Steril. 2010;93:52-6.
Seracchioli R, Mabrouk M, Manuzzi L. Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptomrecurrence after conservative surgery for endometriosis. Hum Reprod. 2009;24:2729-35.
Seracchioli R, Mabrouk M, Frascà C, Manuzzi L, Savelli L, Venturoli S.Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial. Fertil Steril. 2010;94:464-71.
Takamura M, Koga K, Osuga Y et al. Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision. Hum Reprod. 2009;24:3042-8.
Vercellini P, Somigliana E, Daguati R, Vigano P, Meroni F, Crosignani PG. Postoperative oral contraceptive exposure and risk of endometrioma recurrence. Am J Obstet Gynecol. 2008;198:504.e1-5.
Vercellini P, DE Matteis S, Somigliana E, Buggio L, Frattaruolo MP, Fedele L. Long-term adjuvant therapy for the prevention of postoperative endometrioma recurrence: a systematic review and meta-analysis. Acta Obstet Gynecol Scand. 2013;92:8-16.
Abou-Setta AM, Houston B, Al-Inany HG, Farquhar C. Levonorgestrelreleasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery. Cochrane Database Syst Rev. 2013;(1):CD005072.
Tanmahasamut P, Rattanachaiyanont M, Angsuwathana S, Techatraisak K, Indhavivadhana S, Leerasiri P. Postoperative levonorgestrel-releasing intrauterine system for pelvic endometriosis-related pain: a randomized controlled trial. Obstet Gynecol. 2012;119:519-26.
Gomes MK, Ferriani RA, Rosa e Silva JC, Japur de Sá Rosa e Silva AC, Vieira CS, Cândido dos Reis FJ. The levonorgestrel-releasing intrauterine system and endometriosis staging. Fertil Steril. 2007;87:1231-4.
Bayoglu Tekin Y, Dilbaz B, Altinbas SK, Dilbaz S. Postoperative medical treatment of chronic pelvic pain related to severe endometriosis: levonorgestrel-releasing intrauterine system versus gonadotropin-releasing hormone analogue. Fertil Steril. 2011;95:492-6.
Petta CA, Ferriani RA, Abrao MS et al. Randomized clinical trial of a levonorgestrel-releasing intrauterine system and a depot GnRH analogue for the treatment of chronic pelvic pain in women with endometriosis. Hum Reprod. 2005;20:1993-8.
de Ziegler D, Gayet V, Aubriot FX et al. Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes. Fertil Steril. 2010;94:2796-9.
Hughes E, Brown J, Collins JJ, Farquhar C, Fedorkow DM, Vandekerckhove P. Ovulation suppression for endometriosis. Cochrane Database Syst Rev. 2007;(3):CD000155.
Sallam HN, Garcia-Velasco JA, Dias S, Arici A. Long-term pituitary downregulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev. 2006;(1):CD004635
Pabuccu R, Onalan G, Kaya C. GnRH agonist and antagonist protocols for stage I-II endometriosis and endometrioma in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2007;88:832-9.
Hornstein MD, Surrey ES, Weisberg GW, Casino LA. Leuprolide acetate depot and hormonal add-back in endometriosis: a 12-month study. Lupron Add-Back Study Group. Obstet Gynecol. 1998;91:16-24.
Redwine DB. Ovarian endometriosis: a marker for moreextensive pelvic and intestinal disease. Fertil Steril 1999;72:310-5.
Xu XW, Wang LD, Zhu XQ et al. Levonorgestrel-releasing intrauterine system and combined oral contraceptives as conservative treatments for recurrent ovarian endometriosis: a comparative clinical study. Zhonghua Yi Xue Za Zhi. 2011;91:1047-50.
Lee DY, Bae DS, Yoon BK, Choi D. Post-operative cyclic oral contraceptive use after gonadotrophin-releasing hormone agonist treatment effectively prevents endometrioma recurrence. Hum Reprod. 2010;25:3050-4.
Vercellini P, Crosignani P, Somigliana E, Viganò P, Frattaruolo MP, Fedele L. 'Waiting for Godot': a commonsense approach to the medical treatment of endometriosis. Hum Reprod. 2011;26:3-13.
