La N-acétylcysteine dans le choc septique
Mots-clés :
N-acétylcysteine - choc septique - radicaux libres - ischémie reperfusionRésumé
But : Mise au point sur les différentes études évaluant les effets de la N-acetylcysteine dans le choc septique.Méthodes : Recherche effectuée dans la base de données Medline utilisant les mots clés: N-acetylcysteine, septic shock et free radicals;avec une analyse des principaux articles indexés.
Résultats : Le choc septique demeure la principale cause de mortalité en milieu de soins intensifs. La connaissance progressive de la physiopathologie du choc septique, a permis de mettre en évidence la production de radicaux libres ainsi que leurs effets tant au niveau cellulaire que microcirculatoire. La N-acéylcysteine utilisée principalement dans les intoxications au paracétamol,possède des propriétés de lutte contres les agents oxydants. L’explosion de radicaux libres au cours du choc septique a donné lieu a de multiples études évaluant le rôle de la N-acétylcysteine tant pour son rôle anti radicalaire, que pour son action anti-inflammatoire.
Conclusion : La NAC semble jouer un rôle important au cours du choc septique dans le contrôle des radicaux libres ainsi que dans le syndrome inflammatoire Mais ces résultats demeurent contradictoires. Des études plus vastes et plus standardisées devraient permettre de trancher et d’évaluer les effets réels de la NAC au cours du choc septique.
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Références
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