La mutation mitochondriale A3243G dans la population diabétique tunisienne
Mots-clés :
Diabète, population tunisienne, ADN mitochondrial, polymorphisme 3243Résumé
Prérequis : Un excès dans la transmission maternelle du diabète est observé dans la population Tunisienne, en effet, elle est significativement plus importante que la transmission paternelle (p<10-6). Cet excès de transmission du diabète du côté maternel pourrait être le résultat d’un défaut touchant l’ADN mitochondrial
qui se transmet exclusivement de la maman à l’enfant.
But : Evaluer l’atteinte du ADN mitochondrial dans une population tunisienne du diabéttique et la prévalence du A3243G.
Méthodes : Dans la présente étude nous avons recherché la mutation mitochondriale touchant le gène de l’ARNt Leu à la position 3243 du génome mitochondrial chez 280 diabétiques Tunisiens.
Résultats : Les résultats montrent que la fréquence de la substitution A/G de l’ARNt Leu est de l’ordre de 1.07%. Une fréquence comparable à celle retrouvée dans les populations japonaise, allemande et française.
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Références
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