Predictive factors of severe henoch-schonlein nephritis in children: About 34 cases
Keywords:
Henoch Schönlein- Nephritis- Child- PrognosisAbstract
Background: Henoch Schonlein Purpura is the most frequent vasculitis in children. Renal involvement is variable. Renal manifestations vary from isolated microscopic hematuria to the association on nephrotic syndrome to nephritic syndrome.Aim: To determine the predictors of severe Henoch – Schönlein nephritis.
Methods: Retrospective study over 15 years (1996-2010) of 34 chidren, with henoch-schonlein nephritis.
Results: Renal involvement was determined in 68.7%. Mean age was 7.23 years (3-14 years). Renal manifestations were variable. Moderate renal manifestations were noted in 15 cases. Microscopic hematuria was observed in 23.5% of cases and moderate proteinuria with or without hematuria is noted in 20.5% of cases. Severe nephritis was noted in 18 cases: nephrotic syndrome in 29.5 % and nephrotic syndrome associated to nephritic syndrome in 23.5%. Hypertension without urinary anomalies was observed in one case. In univariate analysis, factor predictive of severe nephritis were: male sex, macroscopic hematuria, biologic inflammatory syndrome and leukocytosis. In multivariate analysis, only the leukocytosis was predictor of severity.
Conclusion: In our study, only leukocytosis was predictor of severity in henoch-schönlein nephritis
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References
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