ULCERATIVE COLITIS AND SCHIZOPHRENIA : FORTUITOUS ASSOCIATION OR ETIOPATHOGENIC LINK ?
Keywords:
Schizophrenia, Ulcerative colitis, ComorbidityAbstract
Background: Ulcerative colitis is a chronic inflammatory bowel disease with multiple pathogenic factors. Psychiatric disorder have frequently been associated to ulcerative colitis, the most frequent being depression and anxiety, whereas schizophrenia is unusual.
Aim : Report a new case of ulcerative colitis associated topsychiatric disorder.
Case-report: We report the case of a 42-year-old woman with ulcerative colitis associated with schizophrenia. Although the two diagnoses were concomitant, on questioning, she revealed that digestive symptoms began before psychiatric disorders.
Conclusion: Few cases of schizophrenia associated with ulcerative colitis have been reported in the literature. We discuss epidemiological, etiopathogenic and therapeutic links between the two diseases.
Downloads
References
Sobhani I. Facteurs génétiques et environnementaux dans les maladies inflammatoires chroniques de l'intestin. Rev Med Suisse 2000;58:1718-21.
Andrews H, Barczak P, Allan RN. Psychiatric illness in patients with inflammatory bowel disease. Gut 1987;28:1600-4.
Dohmen K, Yamano Y, Omori F, et al. Ulcerative colitis associated with pyoderma gangrenosum and schizophrenia. A case report. Nippon Shokakibyo Gakkai Zasshi 1991;88:1250-5.
Alcena V, Alexopoulos GS. Ulcerative colitis in association with chronic paranoid schizophrenia: a review of steroid-induced psychiatric disorders. J Clin Gastroenterol 1985;7:400-4
Chiba M, Igarashi K, Gotoh M,et al. A case of ulcerative colitis associated with schizophrenia. Nippon Shokakibyo Gakkai Zasshi 1986; 83:693-6.
Welch CS, Gorham W. Chronic ulcerative colitis with psychosis. Am J Surgery 1941;52:511-2.
Cucino C, Sonnenberg A. The comorbid occurrence of other diagnoses in patients with ulcerative colitis and Crohn's disease. Am J Gastroenterol 2001; 96:2107-12.
West J, Logan RF, Hubbard RB, Card TR. Risk of schizophrenia in people with celiac disease, ulcerative colitis and Crohn's disease: a general population-based study. Aliment Pharmacol Ther 2006;23:71-4.
Vernier G, Cortot A, Gower-Rousseau C, et al. Epidemiology and risk factors of inflammatory bowel diseases. Rev Prat 2005;55:949-61.
Saha S, Chant D, Welham J, McGrath J. A Systematic Review of the Prevalence of Schizophrenia. PLOS medicine 2005;5:413-33.
Pélissolo A, Lemonnier E, Allilaire JF. Troubles délirants et schizophrénie. In : Godeau P, Herson S, Piette JC, (eds) Traité de médecine Paris. Médecine-Sciences Flammarion, 2004; 2637-42
Rothermundt M, Arolt V. Schizophrenia and immunity. Psychoneuroimmunology 2007; 27: 563-77
Karoui S, Fakhfakh R, Daly S, et al. Evaluation des troubles psychologiques chez les patients porteurs de maladies inflammatoires chroniques de l'intestin. Tunis Med 2006; 84:768- 71.
Wiesnagrotzki S, Gathmann P, Kiss A. Ulcerative colitis: a cyclothymic disorder? Psychopathology 1985;18:163-6.
Warrington TP, Bostwick JM. Psychiatric adverse effects of corticosteroids. Mayo Clin Proc 2006;81:1361-7.
Rebrov VG, Lukomski? MI. A case of depression in the treatment of nonspecific ulcerative colitis with sulfasalazine. Klin Med 1989;67:106.
Scherer J. Depression induced by salazosulfapyridine in cyclothymia and Crohn disease. Nervenarzt 1988; 59:371-3.
Jajiç Z, Jajiç I. Acute psychoses in patients with psoriatic arthritis during treatment with sulfasalazine. 1998; 46:43-4.
Labayle D, Delas N, Pariente A, et al. Severe psychiatric disorders associated with severe acute colitis. Gastroenterol Clin Biol 1992;16:639-43.
Larrey D, Lainey E, Blanc P, et al. Acute colitis associated with prolonged administration of neuroleptics. J Clin Gastroenterol 1992;14:64-7.
