CLINICOPATHOLOGICAL CHARACTERISTICS OF SYNCHRONOUS BILATERAL BREAST CARCINOMAS, CASE SERIES OF 30 PATIENTS
Keywords:
Synchronous breast carcinoma, epidemiology, diagnosis, treatment, prognosisAbstract
Aim : The objective of this study is to determine the clinicopathologic characteristics; incidence and prognosis value of synchronous bilateral breast carcinoma (SBBC).
Methods : This is a retrospective study done in Salah Azaiz Institute of Tunis about 30 patients with synchronousbilateral breast carcinomas diagnosed and treated over a 21- years period going from 1977 to 1997. The definition of synchronous breast lesions is the developpement of the contralateral breast cancer within 6 months.
Results : Median age was 49 years. The incidence of SBBC was 0.52%. History family was noted in 3% of our population. Mean tumor size was 40 mm (15-145). Breast conserving therapy was done in 16% of cases (9 patients). Five-year overall survival was 40%. Five year survival rates were 72 and 17% for stage II and III, respectively. Main prognostic factors for survival were lymph node involvement (P=0.004) and disease stage (P=0.02).
Conclusion : Synchronous bilateral breast carcinoma is a rare entity, with a problem of definition concerning the delay of bilaterlisation. Their prognosis is similar to that of unilateral breast carcinoma patients of equal stage. Hence, breast conserving therapy can be used s fely if indicated.
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