Contribution of fetopathological examination in identifying causes of neonatal deaths
DOI:
https://doi.org/10.62438/tunismed.v103i4.5473Keywords:
Neonatal deaths, Neonatological clinical examination, Fetopathological examinationAbstract
Objectives: To determine the concordance between the causes of death reported in the neonatal departement and the data obtained from the fetopathologic examination.
Methods: We included all newborns admitted to the Neonatal Resuscitation Unit who died there before the 28th day of life and in whom a fetopathological examination was performed.
Results: The causes of neonatal deaths were characterized by the dominance of respiratory pathologies (31%) then palliative cares (18%), neurological causes (9%), heart disease (9%), inherited diseases of metabolism (6%) and sudden deaths (6%). A total concordance between fetopathological and neonatological examinations was noted in 27% of the cases, a partial concordance in 40%, a total discordance in 27%, and in only 6% of the cases the fetopathological examination didn’t show any abnormalities.
Conclusion: We emphasize of the importance of fetopathological examination in the determination of the cause of neonatal deaths by providing an exhaustive diagnosis essential to the management of future pregnancies.
Downloads
References
Brodlie M, Laing IA, Keeling JW, McKenzie KJ. Ten years of neonatal autopsies in tertiary referral centre: retrospective study. BMJ. 2002;324(7340):761-3.
Bétrémieux P, Casadevall I, Odent S, Jouan H, Lefrançois C, Naber MC, et al. Autopsy in neonatal death. Arch Fr Pediatr. 1989;46(5):341‑5.
Brand IR, Kaminopetros P, Cave M, Irving HC, Lilford RJ. Specificity of antenatal ultrasound in the Yorkshire Region: a prospective study of 2261 ultrasound detected anomalies. Br J Obstet Gynaecol. 1994;101(5):392‑7.
Jehan I, Harris H, Salat S, Zeb A, Mobeen N, Pasha O, et al. Neonatal mortality, risk factors and causes: a prospective population-based cohort study in urban Pakistan. Bull World Health Organ. 2009;87(2):130‑8.
Blondel B, Bréart G. Mortinatalité et mortalité néonatale. Encycl Med Chir. (Elsevier Masson, Paris), Pédiatrie-Maladies infectieuses, 4-002-F-50, 2004, 11p.
Chahid N, Boudana S, Kabiri M, Mrabet M, Knouni H, Kharbach A, et al. Retentissement fœtal et néonatal de l’hypertension artérielle gravidique : données marocaines. Journal de Pédiatrie et de Puériculture. 2014;27(3):111‑6.
Noria H, Sarah O, Asmaa O. Risk factors for neonatal mortality in the gynecology-obstetrics hospital in the Wilaya of Sidi Bel Abbes, Algeria. Pan Afr Med J. 2015;20(1):387-8.
Boisvert M, Mayer FM. Mortalité infantile et consanguinité dans une population endogame du Québec. Popul Fr Ed. 1994;49(3):685‑724.
Robert-Gnansia E. Risque tératogène des médicaments les plus utilisés : quoi de neuf ? Rev Prat. 2004;(642):231‑5.
Group THSCR. Hyperglycemia and Adverse Pregnancy Outcomes. N Engl J Med. 2008;358(19):1991‑2002.
Cheung NW, Byth K. Population Health Significance of Gestational Diabetes. Diabetes Care. 2003;26(7):2005‑9.
Beischer NA, Wein P, Sheedy MT, Steffen B. Identification and Treatment of Women with Hyperglycaemia Diagnosed During Pregnancy Can Significantly Reduce Perinatal Mortality Rates. Aust N Z J Obstet Gynaecol. 1996;36(3):239‑47.
Persson B, Hanson U. Neonatal morbidities in gestational diabetes mellitus. Diabetes Care. 1998;21 Suppl 2:S79-84.
Schmidt MI, Duncan BB, Reichelt AJ, Branchtein L, Matos MC, Forti AC, et al. Gestational Diabetes Mellitus Diagnosed With a 2-h 75-g Oral Glucose Tolerance Test and Adverse Pregnancy Outcomes. Diabetes Care. 2001;24(7):1151‑5.
Odegard RA, Vatten LJ, Nilsen ST, Salvesen KA, Austgulen R. Preeclampsia and fetal growth. Obstet Gynecol. 2000;96(6):950‑5.
Doron MW, Makhlouf RA, Katz VL, Lawson EE, Stiles AD. Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia. J Pediatr. 1994;125(3):452‑8.
Mouzinho A, Rosenfeld CR, Sanchez PJ, Risser R. Effect of maternal hypertension on neonatal neutropenia and risk of nosocomial infection. Pediatrics. 1992;90(3):430‑5.
Chang EY, Menard MK, Vermillion ST, Hulsey T, Ebeling M. The association between hyaline membrane disease and preeclampsia. Am J Obstet Gynecol. 2004;191(4):1414‑7.
Stoll C, Dott B, Alembik Y, Roth M-P. Etude épidémiologique de l’oligoamnios associé aux malformations congénitales. J Gynecol Obstet Biol Reprod. 1990;19(8):947‑53.
Scott RJ, Goodburn SF. Potter’s syndrome in the second trimester—prenatal screening and pathological findings in 60 cases of oligohydramnios sequence. Prenat Diagn. 1995;15(6):519‑25.
Casey BM, McIntire DD, Leveno KJ. The Continuing Value of the Apgar Score for the Assessment of Newborn Infants. N Engl J Med. 2001;344(7):467‑71.
Gordijn SJ, Erwich JJHM, Khong TY. Value of the perinatal autopsy: critique. Pediatr Dev Pathol. 2002;5(5):480‑8.
DelannoyY, Becart A, Maurage C-A, Cornez R, Hedouin V, Copin M-C, et al. Performing autopsies of all sudden deaths: a public health prevention strategy. Santé publique. 2013;25(2):155-62.
Levieux K, Parural H, Harrewijn I, Manf M, Gras Leguen C. Prise en charge des morts inattendues du nourrisson par les centres de reference français: état des lieux des pratiques en 2013. Arch Pediatr. 2015;22(4):360-7.
Saint-Stéban C, Leray E, Jouan H, Loget P, Venisse A, Roussey M. Peut-on expliquer la mort inattendue du nourrisson? Reflexions à partir d’une série de 80 cas autopsies au CHU de Renne entre 1997 et 2007. Arch Pediatr. 2010;17(8):1231-6
Nasri K, Ben Jemaa N, Chorfi B, Sahraoui M, Masmoudi A, Siala Gaigi S. Birth defects and epidemiological factors in tunisia. Tunis Med. 2024 Sept;102(9): 543-550
Ben Hamida Nouaili E, Chaouachi S, Ben Said A, Marrakchi Z. Determinants of neonatal mortality in a Tunisian population. Tunis Med. 2010 Jan;88(1):42-5.
Additional Files
Published
License
Copyright (c) 2025 La Tunisie Médicale
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
