Cerebral venous thrombosis after first Methotrexate administration by lumbar puncture in a patient with large B cell lymphoma
Keywords:
Cerebral venous thrombosis, diffuse large B cell lymphoma, intrathecal Methotrexate, lumbar punctureAbstract
Cerebral venous thrombosis is a rare consequence of lumbar punctures for intrathecal therapy. We report a patient treated for diffuse large B cell lymphoma with cerebral venous thrombosis after intrathecal Methotrexate administration. In this patient, intrathecal treatment was discontinued and he was successfully treated with high-dose low-molecular-weight heparin subcutaneously.
Haematologist must be aware about neurological symptoms of cerebral venous thrombosis as a complication of lumbar puncture especially among patients with high coagulopathy state.
If neurological symptom occurs, patient should be referred early to neurologist to avoid fatal outcome and neurological deficit.
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