Prognostic value of highly-sensitive troponin in preeclampsia
Abstract
Background : Pre-eclampsia is a pregnancy complication leading to significant morbidity and mortality. High-sensitivity troponin (hs-cTnI ) is
one of the most sensitive cardiac biomarkers, but its variation in preeclampsia remains poorly studied. The aim of our study was to assess the
prognostic value of hyper-sensitive troponin in preeclampsia.
Methods : It was a prospective study including patients with preeclampsia. The exclusion criteria included conditions that may cause an
elevation of hs-cTnI. Preoperative laboratory assessment included the determination of the level of hs-cTnI. The discriminative value of the
preoperative hs-cTnI allowing to predict the onset of complications was evaluated by the ROC curve. Group A included patients whose rate
was above the calculated cutoff, and group B included the others.
Results : Seventy seven patients were included. Complications occurred in 22% of cases. The preoperative hs-cTnI cutoff of 6.3 ng/l
predicted the onset of complications (sensitivity 70.6% / specificity 86.6% / p <0.0001). There was a higher rate of severe pre-eclampsia and
complications, a higher systolic and mean arterial blood pressure values in group A with significant differences. Both groups were comparable
demographically, obstetrically, clinically and biologically.
Conclusion : According to the results of our study, increased values of preoperative hs-cTnI may predict the onset of complications in
pregnancies complicated by preeclampsia.
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References
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