Influenza a/H1n1 pdm 09 in children’s Hospital Bechir Hamza of Tunis
Keywords:
H1N1/09 influenza virus; children.Abstract
Background: Influenza A (H1N1) is a contagious acute respiratory infection caused a pandemic in 2009. The outcome was variable among
populations.
Aim: To describe a clinical spectrum and the outcome of Tunisian children with pandemic H1N1/09 influenza virus
Methods: This is a retrospective, descriptive study of children with pandemic H1N1/09 influenza virus hospitalized in the children’s hospital of
tunis, between November 2009 and February 2010. The diagnosis was made on positive rapid test or PCR.
Results: thirty two children were included. The median age was 12 months. The most frequently symptoms were: fever (87,5%), digestive
disorders ( 59,4%) and dyspnea (15,6%). The mean length of stay was 3,8 days. The outcome was complicated by a bacterial infection (56,3%),
and one death.
Conclusion: Mild form of H1N1/influenza virus is the most common presentation; however severe forms can be observed especially in infants.
Downloads
References
Wiramus S, Martin C.Hospitalized patients with 2009 H1N1 influenza in intensive care unit over the world,epidemiological assessment in January 2010. Ann Fr AnesthReanim. 2010;29: 87-90.
Shannon S, Louie J, Siniscalchi A, et al. Surveillance for pediatric deaths associated with 2009 pandemic influenzaA(H1N1) virus infection-United States. JAMA. 2009;302:1855-7.
Louie J, Acosta M, Winter K, et al. Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California. JAMA. 2009;302:1896-902.
Kumar A, Zarychanski R, Pinto R, et al. Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA. 2009;302:1872-9.
Chowell G, Bertozzi SM, Colchero MA,et al. Severe respiratory disease concurrent with the circulation of H1N1 influenza. N Engl J Med. 2009;361:674-9.
Ministere de la santé pulique.Plan national de riposte à la grippe Aout 2009. H1N1.http://www.atds.org.tn/PlanNationalA(H1N1)v1.pdf
Libster R, Coviello S, Cavalieri ML, etal. Pediatric hospitalizations due to influenza in 2010 in Argentina.NEngl J Med. 2010;363:2472-3.
Bautista E, Chotpitayasunondh T, Gao Z, et al. Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med. 2010;362:1708-19.
Jain S, Kamimoto L, Bramley AM, et al. Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N Engl J Med. 2009;361:1935-44.
Skarbinski J, Jain S, Bramley A, etal. Hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in the United States - September-October 2009. ClinInfect Dis. 2011;52(Suppl 1):S50-9.
Bettinger JA, Sauve LJ, Scheifele DW, et al. Pandemic influenza in Canadian children: a summary of hospitalized pediatric cases. Vaccine. 2010;28:3180-4.
Stein M, Tasher D, Glikman D, et al. Hospitalization of children with influenza A(H1N1) virus in Israel during the 2009 outbreak in Israel: a multicenter survey. Arch PediatrAdolesc Med. 2010;164:1015-22.
Wieching A, Benser J, Kohlhauser-Vollmuth C,et al. Clinical characteristics of pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Northern Bavaria,Germany. BMC Res Notes. 2012;5:304.
Larcombe PJ, Moloney SE, Schmidt PA.Pandemic (H1N1) 2009: a clinical spectrum in the general paediatric population.Arch Dis Child. 2011;96:96-8.
Hackett S, Hill L, Patel J,et al.Clinical characteristics of paediatric H1N1 admissions in Birmingham, UK. Lancet.2009;374:605
O'Riordan S, Barton M, Yau Y,et al. Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza. CMAJ. 2010;182:39-44.
Rello J, Pop-Vicas A.Clinical review: primary influenza viral pneumonia.Crit Care. 2009;13:235. 18.ANZIC Influenza Investigators, Webb SA, Pettilä V,et al.Critical care services and 2009 H1N1 influenza in Australia and New Zealand.NEnglJ Med. 2009 12;361:1925-34.
ANZIC Influenza Investigators, Webb SA, Pettilä V,et al.Critical care services and 2009 H1N1 influenza in Australia and New Zealand.NEnglJ Med. 2009 12;361:1925-34.
Takeuchi M, Yasunaga H, Horiguchi H, Matsuda S. Clinical features of infants hospitalized for 2009 pandemic influenza A (H1N1) in Japan: analysis using a national hospital discharge database Pediatr Infect Dis J.2012;31:368-72.
Ruf BR, Knuf M. The burden of seasonal and pandemic influenza in infants and children.Eur J Pediatr. 2014;173:265-76.
