CENTRAL NERVOUS SYSTEM DYSGERMINOMA A CLINICOPATHOLOGICAL STUDY OF 3 CASES

Authors

  • Selma Bellil Service d'Anatomie et de Cytologie Pathologiques. Hôpital la Rabta
  • Emna Braham Service d'Anatomie et de Cytologie Pathologiques. Hôpital la Rabta
  • Faten Limaiem Service d'anatomie pathologique Hôpital La Rabta Tunis.
  • Khadija Bellil Service d'anatomie pathologique Hôpital La Rabta Tunis.
  • Ines Chelly Service d'anatomie pathologique Hôpital La Rabta Tunis.
  • Amina Mekni Department of Pathology
  • Slim Haouet Department of Pathology
  • Moncef Zitouna Service d'anatomie pathologique Hôpital La Rabta Tunis.
  • Hafedh Jemel Service de Neurochirurgie. Institut national de Neurologie
  • Moncef Khaldi Service de Neurochirurgie. Institut national de Neurologie
  • Nidhameddine Kchir Service d'anatomie pathologique Hôpital La Rabta Tunis.

Keywords:

Dysgerminoma, histology, radiotherapy

Abstract

Background: Intracranial germ cell tumors are rarely seen and typically localize in the pineal or suprasellar region. The largest category of germ cell tumors is dysgerminoma.
Aim: to describe clinicopathological features and immunohistochemical profile of dysgerminomas.
Case report: We report three cases of central nervous system dysgerminomas. There were two young women and a man who were 6, 11 and 23 year-old. They presented with symptoms of insipidus diabetes (n=3) with association to visual field defects in the third case. Radiological findings showed a supra seller lesion in two cases. Double localization in the pineal and suprasellar regions was seen in the third case. Histologic examination and immunohistochemical
study of surgical specimen were consistent with primary central nervous system dysgerminoma.

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References

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Issue

Vol. 87 No. 3 (2009): Issue Mar 2009

Section

Case report

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